| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TPMT (1-245) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TPMT |
| Gene ID: |
7172 |
| Uniprot ID: |
TPMT_HUMAN |
| Immunogen Region: |
1-245 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-245 of human TPMT (NP_000358.1). |
| Immunogen Sequence: |
MDGTRTSLDIEEYSDTEVQK NQVLTLEEWQDKWVNGKTAF HQEQGHQLLKKHLDTFLKGK SGLRVFFPLCGKAVEMKWFA DRGHSVVGVEISELGIQEFF TEQNLSYSEEPITEIPGTKV FKSSSGNISLYCCSIFDLPR TNIGKFDMIWDRGALVAINP GDRKCYADTMFSLLGKKFQY LLCVLSYDPTKHPGPPFYVP HAEIERLFGKICNIRCLEKV DAFEERHKSWGIDCLFEKL |
| Function | Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor. TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. |
| Protein Name | Thiopurine S-MethyltransferaseThiopurine Methyltransferase |
| Database Links | Reactome: R-HSA-156581Reactome: R-HSA-5578995Reactome: R-HSA-9748787 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Thiopurine S-Methyltransferase antibodyAnti-Thiopurine Methyltransferase antibodyAnti-TPMT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
