| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TPCN1 (692-816) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TPCN1 |
| Gene ID: |
53373 |
| Uniprot ID: |
TPC1_HUMAN |
| Immunogen Region: |
692-816 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 692-816 of human TPCN1 (NP_060371.2). |
| Immunogen Sequence: |
FRMNYSRKNQDSEVDGGITL EKEISKEELVAVLELYREAR GASSDVTRLLETLSQMERYQ QHSMVFLGRRSRTKSDLSLK MYQEEIQEWYEEHAREQEQQ RQLSSSAAPAAQQPPGSRQR SQTVT |
| Tissue Specificity | Highest expression found in the heart and kidney, and lowest expression found in the spleen. |
| Post Translational Modifications | N-glycosylated. |
| Function | Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles. Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (Probable). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (Probable). (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm. |
| Protein Name | Two Pore Channel Protein 1Two Pore Calcium Channel Protein 1Voltage-Dependent Calcium Channel Protein Tpc1 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinEndosome MembraneEarly Endosome MembraneRecycling Endosome Membrane |
| Alternative Antibody Names | Anti-Two Pore Channel Protein 1 antibodyAnti-Two Pore Calcium Channel Protein 1 antibodyAnti-Voltage-Dependent Calcium Channel Protein Tpc1 antibodyAnti-TPCN1 antibodyAnti-KIAA1169 antibodyAnti-TPC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
