• Western blot analysis of various lysates using p63 Rabbit polyclonal antibody (STJ114834) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-TP63 antibody (1-160) (STJ114834)

SKU:
STJ114834

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-p63 (1-160) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TP63
Gene ID: 8626
Uniprot ID: P63_HUMAN
Immunogen Region: 1-160
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human p63 (NP_003713.3).
Immunogen Sequence: MNFETSRCATLQYCPDPYIQ RFVETPAHFSWKESYYRSTM SQSTQTNEFLSPEVFQHIWD FLEQPICSVQPIDLNFVDEP SEDGATNKIEISMDCIRMQD SDLSDPMWPQYTNLGLLNSM DQQIQNGSSSTSPYNTDHAQ NSVTAPSPYAQPSSTFDALS
Tissue Specificity Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.
Post Translational Modifications May be sumoylated. Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.
Function Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
Protein Name Tumor Protein 63
P63
Chronic Ulcerative Stomatitis Protein
Cusp
Keratinocyte Transcription Factor Ket
Transformation-Related Protein 63
Tp63
Tumor Protein P73-Like
P73l
P40
P51
Database Links Reactome: R-HSA-139915
Reactome: R-HSA-5620971
Reactome: R-HSA-5628897
Reactome: R-HSA-6803204
Reactome: R-HSA-6803205
Reactome: R-HSA-6803207
Reactome: R-HSA-6803211
Reactome: R-HSA-6804759
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Tumor Protein 63 antibody
Anti-P63 antibody
Anti-Chronic Ulcerative Stomatitis Protein antibody
Anti-Cusp antibody
Anti-Keratinocyte Transcription Factor Ket antibody
Anti-Transformation-Related Protein 63 antibody
Anti-Tp63 antibody
Anti-Tumor Protein P73-Like antibody
Anti-P73l antibody
Anti-P40 antibody
Anti-P51 antibody
Anti-TP63 antibody
Anti-KET antibody
Anti-P63 antibody
Anti-P73H antibody
Anti-P73L antibody
Anti-TP73L antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance