| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TP53BP2 (200-330) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TP53BP2 |
| Gene ID: |
7159 |
| Uniprot ID: |
ASPP2_HUMAN |
| Immunogen Region: |
200-330 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 200-330 of TP53BP2 (NP_001026855.2). |
| Immunogen Sequence: |
RALKGHVEQKRLSNGKLVEE IEQMNNLFQQKQRELVLAVS KVEELTRQLEMLKNGRIDSH HDNQSAVAELDRLYKELQLR NKLNQEQNAKLQQQRECLNK RNSEVAVMDKRVNELRDRLW KKKAALQQKEN |
| Tissue Specificity | Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines. |
| Function | Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. |
| Protein Name | Apoptosis-Stimulating Of P53 Protein 2Bcl2-Binding ProteinBbpRenal Carcinoma Antigen Ny-Ren-51Tumor Suppressor P53-Binding Protein 253bp2P53-Binding Protein 2P53bp2 |
| Database Links | Reactome: R-HSA-139915Reactome: R-HSA-6803204Reactome: R-HSA-6803205Reactome: R-HSA-6803211Reactome: R-HSA-6804759 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusPredominantly Found In The Perinuclear RegionSome Small Fraction Is NuclearSequester In The Cytoplasm On Overexpression Of Ddx42 |
| Alternative Antibody Names | Anti-Apoptosis-Stimulating Of P53 Protein 2 antibodyAnti-Bcl2-Binding Protein antibodyAnti-Bbp antibodyAnti-Renal Carcinoma Antigen Ny-Ren-51 antibodyAnti-Tumor Suppressor P53-Binding Protein 2 antibodyAnti-53bp2 antibodyAnti-P53-Binding Protein 2 antibodyAnti-P53bp2 antibodyAnti-TP53BP2 antibodyAnti-ASPP2 antibodyAnti-BBP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
