| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GITR Ligand/TNFSF18 (52-177) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TNFSF18 |
| Gene ID: |
8995 |
| Uniprot ID: |
TNF18_HUMAN |
| Immunogen Region: |
52-177 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 52-177 of human GITR Ligand/TNFSF18 (NP_005083.2). |
| Immunogen Sequence: |
CSIVMLLFLCSFSWLIFIFL QLETAKEPCMAKFGPLPSKW QMASSEPPCVNKVSDWKLEI LQNGLYLIYGQVAPNANYND VAPFEVRLYKNKDMIQTLTN KSKIQNVGGTYELHVGDTID LIFNSE |
| Tissue Specificity | Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. |
| Function | Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 18Activation-Inducible Tnf-Related LigandAitrlGlucocorticoid-Induced Tnf-Related LigandHgitrl |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Ligand Superfamily Member 18 antibodyAnti-Activation-Inducible Tnf-Related Ligand antibodyAnti-Aitrl antibodyAnti-Glucocorticoid-Induced Tnf-Related Ligand antibodyAnti-Hgitrl antibodyAnti-TNFSF18 antibodyAnti-AITRL antibodyAnti-GITRL antibodyAnti-TL6 antibodyAnti-UNQ149 antibodyAnti-PRO175 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
