| Tissue Specificity | Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain. |
| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. |
| Function | Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 12Apo3 LigandTnf-Related Weak Inducer Of ApoptosisTweak Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 12 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 12 - Secreted Form |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5676594 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTumor Necrosis Factor Ligand Superfamily Member 12Secreted Form: SecretedIsoform Twe-Pril: Cell MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Ligand Superfamily Member 12 antibodyAnti-Apo3 Ligand antibodyAnti-Tnf-Related Weak Inducer Of Apoptosis antibodyAnti-Tweak Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 12 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 12 - Secreted Form antibodyAnti-TNFSF12 antibodyAnti-APO3L antibodyAnti-DR3LG antibodyAnti-UNQ181 antibodyAnti-PRO207 antibody |
Information sourced from Uniprot.org
