Anti-KCNE2 antibody (1-123) (STJ116033)

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STJ116033

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-KCNE2 (1-123) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KCNE2
Gene ID: 9992
Uniprot ID: KCNE2_HUMAN
Immunogen Region: 1-123
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-123 of human KCNE2 (NP_751951.1).
Immunogen Sequence: MSTLSNFTQTLEDVFRRIFI TYMDNWRQNTTAEQEALQAK VDAENFYYVILYLMVMIGMF SFIIVAILVSTVKSKRREHS NDPYHQYIVEDWQEKYKSQI LNLEESKATIHENIGAAGFK MSP
Tissue Specificity Highly expressed in brain, heart, skeletal muscle, pancreas, placenta, kidney, colon and thymus. A small but significant expression is found in liver, ovary, testis, prostate, small intestine and leukocytes. Very low expression, nearly undetectable, in lung and spleen.
Function Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1.forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current. KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability.
Protein Name Potassium Voltage-Gated Channel Subfamily E Member 2
Mink-Related Peptide 1
Minimum Potassium Ion Channel-Related Peptide 1
Potassium Channel Subunit Beta Mirp1
Database Links Reactome: R-HSA-5576890
Reactome: R-HSA-5576893
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Apical Cell Membrane
Single-Pass Membrane Protein
Colocalizes With Kcnb1 At The Plasma Membrane
Alternative Antibody Names Anti-Potassium Voltage-Gated Channel Subfamily E Member 2 antibody
Anti-Mink-Related Peptide 1 antibody
Anti-Minimum Potassium Ion Channel-Related Peptide 1 antibody
Anti-Potassium Channel Subunit Beta Mirp1 antibody
Anti-KCNE2 antibody

Information sourced from Uniprot.org

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