| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRAIL R2 (N-Term) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS + 0.02% NaN3 |
| Purification: |
Antigen Affinity Purified |
| Dilution Range: |
WB 1:500-1:1000IHCICCIP |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TNFRSF10B |
| Gene ID: |
8795 |
| Uniprot ID: |
TR10B_HUMAN |
| Immunogen Region: |
N-Term |
| Specificity: |
Reacts with the N terminus of the human TRAIL-R2 protein. |
| Immunogen: |
Synthetic peptide corresponding to amino acids from the N-terminal region of human TRAIL R2 protein |
| Post Translational Modifications | (Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3. |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 10bDeath Receptor 5Tnf-Related Apoptosis-Inducing Ligand Receptor 2Trail Receptor 2Trail-R2Cd Antigen Cd262 |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-202733Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-6803211Reactome: R-HSA-69416Reactome: R-HSA-75158 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 10b antibodyAnti-Death Receptor 5 antibodyAnti-Tnf-Related Apoptosis-Inducing Ligand Receptor 2 antibodyAnti-Trail Receptor 2 antibodyAnti-Trail-R2 antibodyAnti-Cd Antigen Cd262 antibodyAnti-TNFRSF10B antibodyAnti-DR5 antibodyAnti-KILLER antibodyAnti-TRAILR2 antibodyAnti-TRICK2 antibodyAnti-ZTNFR9 antibodyAnti-UNQ160 antibodyAnti-PRO186 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
