| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TMX1 |
| Gene ID: | 81542 |
| Uniprot ID: | TMX1_HUMAN |
| Immunogen Region: | 210-280 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-280 of human TMX1 (NP_110382.3). |
| Immunogen Sequence: | KRRRPQPYPYPSKKLLSESA QPLKKVEEEQEADEEDVSEE EAESKEGTNKDFPQNAIRQR SLGPSLATDKS |
| Tissue Specificity | Ubiquitous. Highly expressed in kidney, liver, placenta and lung. |
| Post Translational Modifications | Palmitoylated.palmitoylation is required for localization to mitochondria-associated endoplasmic reticulum membrane (MAM). |
| Function | Thiredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol. The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids. Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds. Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane. Involved in endoplasmic reticulum-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane. Acts as a negative regulator of platelet aggregation following secretion in the extracellular space. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals. Regulates endoplasmic reticulum-mitochondria Ca(2+) flux. |
| Protein Name | Thioredoxin-Related Transmembrane Protein 1 Protein Disulfide-Isomerase Tmx1 Thioredoxin Domain-Containing Protein 1 Transmembrane Trx-Related Protein |
| Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type I Membrane Protein Mitochondrion Membrane Secreted Predominantly Found In The Endoplasmic Reticulum Secreted In The Extracellular Space Following Thrombin Stimulation Localizes To Mitochondria-Associated Endoplasmic Reticulum Membrane (Mam) Palmitoylation Is Required For Mam Localization |
| Alternative Antibody Names | Anti-Thioredoxin-Related Transmembrane Protein 1 antibody Anti-Protein Disulfide-Isomerase Tmx1 antibody Anti-Thioredoxin Domain-Containing Protein 1 antibody Anti-Transmembrane Trx-Related Protein antibody Anti-TMX1 antibody Anti-TMX antibody Anti-TXNDC antibody Anti-TXNDC1 antibody Anti-PSEC0085 antibody Anti-UNQ235 antibody Anti-PRO268 antibody |
Information sourced from Uniprot.org