| Tissue Specificity | High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract. Coexpressed with ACE2 within mature enterocytes. |
| Post Translational Modifications | Proteolytically processed.probably by an autocatalytic mechanism. |
| Function | Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity. Seems to be capable of activating ENaC. (Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry. |
| Protein Name | Transmembrane Protease Serine 4Channel-Activating Protease 2Caph2Membrane-Type Serine Protease 2Mt-Sp2 Cleaved Into - Transmembrane Protease Serine 4 Catalytic Chain |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTransmembrane Protease Serine 4 Catalytic Chain: SecretedActivated By Cleavage And Secreted |
| Alternative Antibody Names | Anti-Transmembrane Protease Serine 4 antibodyAnti-Channel-Activating Protease 2 antibodyAnti-Caph2 antibodyAnti-Membrane-Type Serine Protease 2 antibodyAnti-Mt-Sp2 Cleaved Into - Transmembrane Protease Serine 4 Catalytic Chain antibodyAnti-TMPRSS4 antibodyAnti-TMPRSS3 antibodyAnti-UNQ776 antibodyAnti-PRO1570 antibody |
Information sourced from Uniprot.org
