| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TMPRSS11D (42-292) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TMPRSS11D |
| Gene ID: |
9407 |
| Uniprot ID: |
TM11D_HUMAN |
| Immunogen Region: |
42-292 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 42-292 of human TMPRSS11D (NP_004253.1). |
| Immunogen Sequence: |
AFDQKSYFYRSSFQLLNVEY NSQLNSPATQEYRTLSGRIE SLITKTFKESNLRNQFIRAH VAKLRQDGSGVRADVVMKFQ FTRNNNGASMKSRIESVLRQ MLNNSGNLEINPSTEITSLT DQAAANWLINECGAGPDLIT LSEQRILGGTEAEEGSWPWQ VSLRLNNAHHCGGSLINNMW ILTAAHCFRSNSNPRDWIAT SGISTTFPKLRMRVRNILIH NNYKSATHENDIALVRLEN |
| Tissue Specificity | Located in the cells of the submucosal serous glands of the bronchi and trachea. |
| Function | May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions.spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate. |
| Protein Name | Transmembrane Protease Serine 11dAirway Trypsin-Like Protease Cleaved Into - Transmembrane Protease Serine 11d Non-Catalytic Chain - Transmembrane Protease Serine 11d Catalytic Chain |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinActivated By Cleavage And SecretedTransmembrane Protease Serine 11d Catalytic Chain: Secreted |
| Alternative Antibody Names | Anti-Transmembrane Protease Serine 11d antibodyAnti-Airway Trypsin-Like Protease Cleaved Into - Transmembrane Protease Serine 11d Non-Catalytic Chain - Transmembrane Protease Serine 11d Catalytic Chain antibodyAnti-TMPRSS11D antibodyAnti-HAT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
