| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TMEM74 |
| Gene ID: | 157753 |
| Uniprot ID: | TMM74_HUMAN |
| Immunogen Region: | 1-180 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human TMEM74 (NP_694560.1). |
| Immunogen Sequence: | MELHYLAKKSNQADLCDARD WSSRGLPGDQADTAATRAAL CCQKQCASTPRATEMEGSKL SSSPASPSSSLQNSTLQPDA FPPGLLHSGNNQITAERKVC NCCSQELETSFTYVDKNINL EQRNRSSPSAKGHNHPGELG WENPNEWSQEAAISLISEEE DDTSSEATSSGKSIDYGFIS |
| Tissue Specificity | Expressed in heart, lung, and placenta. |
| Function | Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction. |
| Protein Name | Transmembrane Protein 74 |
| Cellular Localisation | Lysosome Membrane Multi-Pass Membrane Protein Cytoplasmic Vesicle Autophagosome Membrane |
| Alternative Antibody Names | Anti-Transmembrane Protein 74 antibody Anti-TMEM74 antibody |
Information sourced from Uniprot.org