| Function | Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH. Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis. Regulation of lumenal pH stability is required for autophagosome-lysosome fusion. Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes. Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors. The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation. The lysoK(GF) complex is required to protect neurons against stress-induced damage. |
| Protein Name | Endosomal/Lysosomal Proton Channel Tmem175Potassium Channel Tmem175Transmembrane Protein 175Htmem175 |
| Cellular Localisation | Endosome MembraneMulti-Pass Membrane ProteinLysosome Membrane |
| Alternative Antibody Names | Anti-Endosomal/Lysosomal Proton Channel Tmem175 antibodyAnti-Potassium Channel Tmem175 antibodyAnti-Transmembrane Protein 175 antibodyAnti-Htmem175 antibodyAnti-TMEM175 antibody |
Information sourced from Uniprot.org
