| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TKTL1 (220-340) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TKTL1 |
| Gene ID: |
8277 |
| Uniprot ID: |
TKTL1_HUMAN |
| Immunogen Region: |
220-340 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 220-340 of human TKTL1 (NP_036385.3). |
| Immunogen Sequence: |
RGTPSIEDAESWHAKPMPRE RADAIIKLIESQIQTSRNLD PQPPIEDSPEVNITDVRMTS PPDYRVGDKIATRKACGLAL AKLGYANNRVVVLDGDTRYS TFSEIFNKEYPERFIECFMA E |
| Tissue Specificity | Widely expressed. Expressed in endothelial cells and in peripheral neurons (at protein level). Isoform 3: Not expressed in fetal neocortex. Isoform 4: Expressed in fetal neocortex. |
| Function | Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Isoform 4: During fetal neocortex development, may be essential to maintain the full number of basal radial glia (bRG). bRG are neural progenitor cells that undergo asymmetric divisions, generating a bRG (self-renewal) and a neuron, in contrast to basal intermediate progenitors (bIPs), which typically divide once to give rise to 2 neurons. bRG generate more cortical neurons over time than bIPs. |
| Protein Name | Transketolase-Like Protein 1Transketolase 2Tk 2Transketolase-Related Protein |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Transketolase-Like Protein 1 antibodyAnti-Transketolase 2 antibodyAnti-Tk 2 antibodyAnti-Transketolase-Related Protein antibodyAnti-TKTL1 antibodyAnti-TKR antibodyAnti-TKT2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
