• Immunohistochemistry of paraffin-embedded human lung cancer using TIAM1 antibody (STJ112290) at dilution of 1:100 (40x lens).
  • Immunohistochemistry of paraffin-embedded human colon carcinoma using TIAM1 antibody (STJ112290) at dilution of 1:100 (40x lens).
  • Western blot analysis of extracts of Rat testis, using TIAM1 antibody (STJ112290) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit.Exposure time: 30s.

Anti-TIAM1 antibody (STJ112290)

SKU:
STJ112290

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Host: Rabbit
Applications: WB, IHC
Reactivity: Human, Rat
Short Description: Rabbit polyclonal anti-TIAM1 antibody is suitable for use in Western Blot and Immunohistochemistry.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Polyclonal
Conjugation: Unconjugated
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification: Affinity purification
Storage Instruction: Store at-20°C. Avoid freeze/thaw cycles.
Isotype: IgG
Dilution Range: WB: 1:200-1:2000
IHC: 1:50-1:200
Uniprot ID: TIAM1_HUMAN
Gene ID: 7074
Gene Symbol: TIAM1
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1392-1591 of human TIAM1 (NP_003244.2).
Function Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.
Protein Name T-Lymphoma Invasion And Metastasis-Inducing Protein 1
Tiam-1
Database Links Reactome: R-HSA-193648
Reactome: R-HSA-194840
Reactome: R-HSA-3928662
Reactome: R-HSA-3928665
Reactome: R-HSA-416482
Reactome: R-HSA-9032845
Cellular Localisation Cell Junction
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Detected At The Boundary Between Cells With Actin-Rich Protrusions
Presence Of Krit1
Cdh5 And Rap1b Is Required For Its Localization To The Cell Junction
Alternative Antibody Names Anti-T-Lymphoma Invasion And Metastasis-Inducing Protein 1 antibody
Anti-Tiam-1 antibody
Anti-TIAM1 antibody

Information sourced from Uniprot.org

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