| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-THSD7A (48-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
THSD7A |
| Gene ID: |
221981 |
| Uniprot ID: |
THS7A_HUMAN |
| Immunogen Region: |
48-350 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 48-350 of human THSD7A (NP_056019.1). |
| Immunogen Sequence: |
AAQGEAEAPTLYLWKTGPWG RCMGDECGPGGIQTRAVWCA HVEGWTTLHTNCKQAERPNN QQNCFKVCDWHKELYDWRLG PWNQCQPVISKSLEKPLECI KGEEGIQVREIACIQKDKDI PAEDIICEYFEPKPLLEQAC LIPCQQDCIVSEFSAWSECS KTCGSGLQHRTRHVVAPPQF GGSGCPNLTEFQVCQSSPCE AEELRYSLHVGPWSTCSMPH SRQVRQARRRGKNKEREKD |
| Tissue Specificity | Detected on kidney podocytes along the glomerular capillary wall (at protein level). |
| Post Translational Modifications | Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form. Extensively N-glycosylated. |
| Function | Thrombospondin type-1 domain-containing protein 7A: Plays a role in actin cytoskeleton rearrangement. Thrombospondin type-1 domain-containing protein 7A, soluble form: The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism. |
| Protein Name | Thrombospondin Type-1 Domain-Containing Protein 7a Cleaved Into - Thrombospondin Type-1 Domain-Containing Protein 7a - Soluble Form |
| Database Links | Reactome: R-HSA-5083635Reactome: R-HSA-5173214 |
| Cellular Localisation | Thrombospondin Type-1 Domain-Containing Protein 7a: Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionDetected On Podocyte Foot ProcessesThrombospondin Type-1 Domain-Containing Protein 7aSoluble Form: SecretedProteolytic Cleavage In The Extracellular Region Generates A 210 Kda Soluble Form |
| Alternative Antibody Names | Anti-Thrombospondin Type-1 Domain-Containing Protein 7a Cleaved Into - Thrombospondin Type-1 Domain-Containing Protein 7a - Soluble Form antibodyAnti-THSD7A antibodyAnti-KIAA0960 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
