| Tissue Specificity | Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation. |
| Post Translational Modifications | Phosphorylated. |
| Function | Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. inhibits AKT1 phosphorylation and activity. enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. |
| Protein Name | Acyl-Coenzyme A Thioesterase Them4Acyl-Coa Thioesterase Them4Carboxyl-Terminal Modulator ProteinThioesterase Superfamily Member 4 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-165158Reactome: R-HSA-199418Reactome: R-HSA-389357Reactome: R-HSA-5218920Reactome: R-HSA-77289 |
| Cellular Localisation | Cell MembraneCell ProjectionRuffle MembraneCytoplasmMitochondrionMitochondrion Inner MembranePeripheral Membrane ProteinMitochondrion Intermembrane SpaceReleased From The Mitochondria Into The Cytosol In Response To Apoptotic Stimuli |
| Alternative Antibody Names | Anti-Acyl-Coenzyme A Thioesterase Them4 antibodyAnti-Acyl-Coa Thioesterase Them4 antibodyAnti-Carboxyl-Terminal Modulator Protein antibodyAnti-Thioesterase Superfamily Member 4 antibodyAnti-THEM4 antibodyAnti-CTMP antibody |
Information sourced from Uniprot.org
