| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TFR2 |
| Gene ID: | 7036 |
| Uniprot ID: | TFR2_HUMAN |
| Immunogen Region: | 130-330 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-330 of human TFR2 (NP_003218.2). |
| Immunogen Sequence: | FHQGRLYWSDLQAMFLQFLG EGRLEDTIRQTSLRERVAGS AGMAALTQDIRAALSRQKLD HVWTDTHYVGLQFPDPAHPN TLHWVDEAGKVGEQLPLEDP DVYCPYSAIGNVTGELVYAH YGRPEDLQDLRARGVDPVGR LLLVRVGVISFAQKVTNAQD FGAQGVLIYPEPADFSQDPP KPSLSSQQAVYGHVHLGTGD P |
| Tissue Specificity | Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly. |
| Function | Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. |
| Protein Name | Transferrin Receptor Protein 2Tfr2 |
| Database Links | Reactome: R-HSA-917977 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinIsoform Beta: CytoplasmLacks The Transmembrane DomainProbably Intracellular |
| Alternative Antibody Names | Anti-Transferrin Receptor Protein 2 antibodyAnti-Tfr2 antibodyAnti-TFR2 antibody |
Information sourced from Uniprot.org