| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-TFDP2 (287-386) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:200-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TFDP2 |
| Gene ID: | 7029 |
| Uniprot ID: | TFDP2_HUMAN |
| Immunogen Region: | 287-386 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 287-386 of human TFDP2 (NP_006277.1). |
| Immunogen Sequence: | GYITDISTGPSWLNQGLLLN STQSVSNLDLTTGATLPQSS VNQGLCLDAEVALATGQFLA PNSHQSSSAASHCSESRGET PCSFNDEDEEDDEEDSSSPE |
| Tissue Specificity | High levels in heart and skeletal muscle. Also found in placenta, kidney, brain, lung and liver. The presence as well as the abundance of the different transcripts appear to vary significantly in different tissues and cell lines. |
| Post Translational Modifications | Ser-24 is probably phosphorylated by CDK2. |
| Function | Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTCCGCGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters. |
| Protein Name | Transcription Factor Dp-2E2f Dimerization Partner 2 |
| Database Links | Reactome: R-HSA-111448Reactome: R-HSA-113501Reactome: R-HSA-1362277Reactome: R-HSA-1362300Reactome: R-HSA-139915Reactome: R-HSA-1538133Reactome: R-HSA-1912408Reactome: R-HSA-2173796Reactome: R-HSA-2559580Reactome: R-HSA-2559585Reactome: R-HSA-6804114Reactome: R-HSA-69202Reactome: R-HSA-69205Reactome: R-HSA-69231Reactome: R-HSA-69656Reactome: R-HSA-8953750Reactome: R-HSA-9616222Reactome: R-HSA-9661069 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Dp-2 antibodyAnti-E2f Dimerization Partner 2 antibodyAnti-TFDP2 antibodyAnti-DP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
