| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TFCP2L1 (360-430) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TFCP2L1 |
| Gene ID: |
29842 |
| Uniprot ID: |
TF2L1_HUMAN |
| Immunogen Region: |
360-430 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 360-430 of human TFCP2L1 (NP_055368.1). |
| Immunogen Sequence: |
NAIKGRNVRPKMTIYVCQEL EQNRVPLQQKRDGSGDSNLS VYHAIFLEELTTLELIEKIA NLYSISPQHIH |
| Tissue Specificity | Highly expressed in placental JEG-3 cells and very low levels of expression in non-steroidogenic cells. No expression was seen in adrenal NCI-H295A cells or in adrenal tissue. |
| Function | Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling. Required for normal duct development in the salivary gland and kidney. Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively. Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1. Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct. JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs. Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation. Modulates the placental expression of CYP11A1. |
| Protein Name | Transcription Factor Cp2-Like Protein 1Cp2-Related Transcriptional Repressor 1Crtr-1Transcription Factor Lbp-9 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Cp2-Like Protein 1 antibodyAnti-Cp2-Related Transcriptional Repressor 1 antibodyAnti-Crtr-1 antibodyAnti-Transcription Factor Lbp-9 antibodyAnti-TFCP2L1 antibodyAnti-CRTR1 antibodyAnti-LBP9 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
