| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TERF2IP (1-280) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TERF2IP |
| Gene ID: |
54386 |
| Uniprot ID: |
TE2IP_HUMAN |
| Immunogen Region: |
1-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human TERF2IP (NP_061848.2). |
| Immunogen Sequence: |
MAEAMDLGKDPNGPTHSSTL FVRDDGSSMSFYVRPSPAKR RLSTLILHGGGTVCRVQEPG AVLLAQPGEALAEASGDFIS TQYILDCVERNERLELEAYR LGPASAADTGSEAKPGALAE GAAEPEPQRHAGRIAFTDAD DVAILTYVKENARSPSSVTG NALWKAMEKSSLTQHSWQSL KDRYLKHLRGQEHKYLLGDA PVSPSSQKLKRKAEEDPEAA DSGEPQNKRTPDLPEEEYV |
| Tissue Specificity | Ubiquitous. Highly expressed. |
| Function | Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. |
| Protein Name | Telomeric Repeat-Binding Factor 2-Interacting Protein 1Terf2-Interacting Telomeric Protein 1Trf2-Interacting Telomeric Protein 1Dopamine Receptor-Interacting Protein 5Repressor/Activator Protein 1 HomologRap1 HomologHrap1 |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110330Reactome: R-HSA-110331Reactome: R-HSA-1221632Reactome: R-HSA-171306Reactome: R-HSA-171319Reactome: R-HSA-174411Reactome: R-HSA-174414Reactome: R-HSA-174417Reactome: R-HSA-174430Reactome: R-HSA-174437Reactome: R-HSA-2559586Reactome: R-HSA-9670095 |
| Cellular Localisation | NucleusCytoplasmChromosomeTelomereAssociates With ChromosomesBoth At Telomeres And In Extratelomeric SitesAlso Exists As A Cytoplasmic FormWhere It Associates With The Ikk Complex |
| Alternative Antibody Names | Anti-Telomeric Repeat-Binding Factor 2-Interacting Protein 1 antibodyAnti-Terf2-Interacting Telomeric Protein 1 antibodyAnti-Trf2-Interacting Telomeric Protein 1 antibodyAnti-Dopamine Receptor-Interacting Protein 5 antibodyAnti-Repressor/Activator Protein 1 Homolog antibodyAnti-Rap1 Homolog antibodyAnti-Hrap1 antibodyAnti-TERF2IP antibodyAnti-DRIP5 antibodyAnti-RAP1 antibodyAnti-PP8000 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
