• Western blot analysis of extracts of various cell lines, using TEAD2 antibody (STJ119529) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Anti-TEAD2 antibody (217-280) (STJ119529)

SKU:
STJ119529

£188.50 - £310.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TEAD2 (217-280) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TEAD2
Gene ID: 8463
Uniprot ID: TEAD2_HUMAN
Immunogen Region: 217-280
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 217-280 of human TEAD2 (NP_003589.1).
Immunogen Sequence: AWQARGLGTARLQLVEFSAF VEPPDAVDSYQRHLFVHISQ HCPSPGAPPLESVDVRQIYD KFPE
Function Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Protein Name Transcriptional Enhancer Factor Tef-4
Tea Domain Family Member 2
Tead-2
Database Links Reactome: R-HSA-2032785
Reactome: R-HSA-8951671
Reactome: R-HSA-9796292
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Transcriptional Enhancer Factor Tef-4 antibody
Anti-Tea Domain Family Member 2 antibody
Anti-Tead-2 antibody
Anti-TEAD2 antibody
Anti-TEF4 antibody

Information sourced from Uniprot.org

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