| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TBC1D5 (446-795) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TBC1D5 |
| Gene ID: |
9779 |
| Uniprot ID: |
TBCD5_HUMAN |
| Immunogen Region: |
446-795 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 446-795 of human TBC1D5 (NP_055559.1). |
| Immunogen Sequence: |
NAKGAPLNINKVSNSLINFG RKLISPAMAPGSAGGPVPGG NSSSSSSVVIPTRTSAEAPS HHLQQQQQQQRLMKSESMPV QLNKGLSSKNISSSPSVESL PGGREFTGSPPSSATKKDSF FSNISRSRSHSKTMGRKESE EELEAQISFLQGQLNDLDAM CKYCAKVMDTHLVNIQDVIL QENLEKEDQILVSLAGLKQI KDILKGSLRFNQSQLEAEEN EQITIADNHYCSSGQGQGR |
| Function | May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol.at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN).the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes. |
| Protein Name | Tbc1 Domain Family Member 5 |
| Cellular Localisation | Endosome MembraneCytoplasmic VesicleAutophagosomeDuring Starvation Induced Autophagy Is Relocalized From Endosomal Localization To Lc3-Positive Autophagosomes |
| Alternative Antibody Names | Anti-Tbc1 Domain Family Member 5 antibodyAnti-TBC1D5 antibodyAnti-KIAA0210 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
