| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PLAA (536-795) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLAA |
| Gene ID: |
9373 |
| Uniprot ID: |
PLAP_HUMAN |
| Immunogen Region: |
536-795 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 536-795 of human PLAA (NP_001026859.1). |
| Immunogen Sequence: |
PKKEAVTFDQANPTQILGKL KELNGTAPEEKKLTEDDLIL LEKILSLICNSSSEKPTVQQ LQILWKAINCPEDIVFPALD ILRLSIKHPSVNENFCNEKE GAQFSSHLINLLNPKGKPAN QLLALRTFCNCFVGQAGQKL MMSQRESLMSHAIELKSGSN KNIHIALATLALNYSVCFHK DHNIEGKAQCLSLISTILEV VQDLEATFRLLVALGTLISD DSNAVQLAKSLGVDSQIKK |
| Function | Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis. |
| Protein Name | Phospholipase A-2-Activating ProteinPla2pPlap |
| Cellular Localisation | NucleusCytoplasmSynapseRecruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains |
| Alternative Antibody Names | Anti-Phospholipase A-2-Activating Protein antibodyAnti-Pla2p antibodyAnti-Plap antibodyAnti-PLAA antibodyAnti-PLAP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
