| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TBC1D23 (250-600) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TBC1D23 |
| Gene ID: |
55773 |
| Uniprot ID: |
TBC23_HUMAN |
| Immunogen Region: |
250-600 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 250-600 of human TBC1D23 (NP_001186127.1). |
| Immunogen Sequence: |
SDSKEEVIKFLENTPSSLNI EDIEDLFSLAQYYCSKTPAS FRKDNHHLFGSTLLGIKDDD ADLSQALCLAISVSEILQAN QLQGEGVRFFVVDCRPAEQY NAGHLSTAFHLDSDLMLQNP SEFAQSVKSLLEAQKQSIES GSIAGGEHLCFMGSGREEED MYMNMVLAHFLQKNKEYVSI ASGGFMALQQHLADINVDGP ENGYGHWIASTSGSRSSINS VDGESPNGSSDRGMKSLVN |
| Tissue Specificity | Isoform 1: Widely expressed, including in fetal adult brain (corpus callosum, pons, cerebellum), spinal cord, heart, skeletal muscle, thymus and bone marrow, and at lower levels in spleen. Hardly detected in liver, kidney, colon and testis. Isoform 2: Expressed at high levels in liver, kidney, colon and testis. Hardly detected in tissues expressing high levels of isoform 1. Expressed at low levels in spleen. |
| Function | Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. |
| Protein Name | Tbc1 Domain Family Member 23Hcv Non-Structural Protein 4a-Transactivated Protein 1 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi NetworkCytoplasmic VesicleLocalization To The Trans-Golgi Is Regulated By Arl1 And Arl5b/Arl8Arl1 Increases Golgi LocalizationWhile Arl5b Decreases ItRecruitment To The Trans-Golgi Network Requires The Presence Of Golga1 And Golga4But Not That Of Fam91a1Recruited On Ap-1-Derived Vesicles By Wdr11 Complex |
| Alternative Antibody Names | Anti-Tbc1 Domain Family Member 23 antibodyAnti-Hcv Non-Structural Protein 4a-Transactivated Protein 1 antibodyAnti-TBC1D23 antibodyAnti-NS4ATP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
