| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TAF10 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TAF10 |
| Gene ID: |
6881 |
| Uniprot ID: |
TAF10_HUMAN |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human TAF10 (NP_006275.1). |
| Immunogen Sequence: |
PSAANGDVKPVVSSTPLVDF LMQLEDYTPTIPDAVTGYYL NRAGFEASDPRIIRLISLAA QKFISDIANDALQHCKMKGT ASGSSRSKSKDRKYTLTMED LTPALSEYGINVKKPHYFT |
| Post Translational Modifications | Monomethylated at Lys-189 by SETD7, leading to increased affinity for RNA polymerase II. Lysine deamination at Lys-189 to form allysine is mediated by LOXL2. Allysine formation by LOXL2 results in release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription. |
| Function | The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF10 is also component of the PCAF histone acetylase complex, the TATA-binding protein-free TAF complex (TFTC) and the STAGA transcription coactivator-HAT complex. May regulate cyclin E expression. |
| Protein Name | Transcription Initiation Factor Tfiid Subunit 10Staf28Transcription Initiation Factor Tfiid 30 Kda SubunitTaf(Ii30Tafii-30Tafii30 |
| Database Links | Reactome: R-HSA-167161Reactome: R-HSA-167162Reactome: R-HSA-167172Reactome: R-HSA-3214847Reactome: R-HSA-5689880Reactome: R-HSA-674695Reactome: R-HSA-6804756Reactome: R-HSA-73776Reactome: R-HSA-73779Reactome: R-HSA-75953Reactome: R-HSA-76042 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Initiation Factor Tfiid Subunit 10 antibodyAnti-Staf28 antibodyAnti-Transcription Initiation Factor Tfiid 30 Kda Subunit antibodyAnti-Taf(Ii30 antibodyAnti-Tafii-30 antibodyAnti-Tafii30 antibodyAnti-TAF10 antibodyAnti-TAF2A antibodyAnti-TAF2H antibodyAnti-TAFII30 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
