| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TACR3 |
| Gene ID: | 6870 |
| Uniprot ID: | NK3R_HUMAN |
| Immunogen Region: | 356-465 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 356-465 of human TACR3 (NP_001050.1). |
| Immunogen Sequence: | YCCLNKRFRAGFKRAFRWCP FIKVSSYDELELKTTRFHPN RQSSMYTVTRMESMTVVFDP NDADTTRSSRKKRATPRDPS FNGCSRRNSKSASATSSFIS SPYTSVDEYS |
| Post Translational Modifications | The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue. |
| Function | This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. |
| Protein Name | Neuromedin-K ReceptorNkrNk-3 ReceptorNk-3rNeurokinin B ReceptorTachykinin Receptor 3 |
| Database Links | Reactome: R-HSA-380095Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Neuromedin-K Receptor antibodyAnti-Nkr antibodyAnti-Nk-3 Receptor antibodyAnti-Nk-3r antibodyAnti-Neurokinin B Receptor antibodyAnti-Tachykinin Receptor 3 antibodyAnti-TACR3 antibodyAnti-NK3R antibodyAnti-TAC3R antibody |
Information sourced from Uniprot.org