| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SYNPO2 (1-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SYNPO2 |
| Gene ID: |
171024 |
| Uniprot ID: |
SYNP2_HUMAN |
| Immunogen Region: |
1-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SYNPO2 (NP_597734.2). |
| Immunogen Sequence: |
MGTGDFICISMTGGAPWGFR LQGGKEQKQPLQVAKIRNQS KASGSGLCEGDEVVSINGNP CADLTYPEVIKLMESITDSL QMLIKRPSSGISEALISENE NKNLEHLTHGGYVESTTLQI RPATKTQCTEFFLAPVKTEV PLAENQRSGPDCAGSLKEET GPSYQRAPQMPDSQRGRVAE ELILREKVEAVQPGPVVELQ LSLSQERHKGASGPLVALPG AEKSKSPDPDPNLSHDRIV |
| Tissue Specificity | Expressed in heart muscle. Isoform 5 is specifically expressed in skeletal muscle. |
| Post Translational Modifications | Phosphorylated by PKA, and by CaMK2 at multiple sites. Dephosphorylated by calcineurin.abrogating interaction with YWHAB and impairing nuclear import. Phosphorylated by ILK. |
| Function | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension.may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes. Involved in regulation of cell migration. May be a tumor suppressor. Isoform 1: Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body. Isoform 2: Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. Isoform 3: Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles. Isoform 4: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers. Isoform 5: Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade.can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia. Can induce formation of thick, irregular actin bundles in the cell body.the induced actin network is associated with enhanced cell migration in vitro. |
| Protein Name | Synaptopodin-2Genethonin-2Myopodin |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMyofibrilSarcomereZ LineCell JunctionFocal AdhesionShuttles Between The Nucleus And The Cytoplasm In A Differentiation-Dependent And Stress-Induced FashionIn Undifferentiated Myoblasts Strongly Expressed In The NucleusAfter Induction Of Myotube Differentiation Is Located To Both Nucleus And Cytoplasm Along Acting FilamentsAnd In Differentiated Myotubes Is Located At The Z LinesUpon Stress Redistributes From Cytoplasm Of Myoblasts And Myotubes To The NucleusNuclear Import Is Kpna2-Dependent And Promoted By Phosphorylation By Pka And/Or Camk2And Inhibition Of CalcineurinThe Nuclear Export Is Xpo1-DependentLocalized In A Fiber-Like PatternPartly Overlapping With Filamentous ActinIsoform 1: CytoplasmLocalizes To Induced Actin Bundles With Contiguous StainingIsoform 2: CytoplasmLocalizes To Induced Actin Bundles With Punctuate StainingIsoform 3: CytoplasmLocalizes To Induced Irregular Actin Bundles With Contiguous And Punctuated StainingIsoform 4: CytoplasmIsoform 5: Cytoplasm |
| Alternative Antibody Names | Anti-Synaptopodin-2 antibodyAnti-Genethonin-2 antibodyAnti-Myopodin antibodyAnti-SYNPO2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
