| Short Description : | Rabbit monoclonal SynGAP (1244-1343) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S3MR |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SYNGAP1 |
| Gene ID: | 8831 |
| Uniprot ID: | SYGP1_HUMAN |
| Immunogen Region: | 1244-1343 |
| Immunogen Sequence: | SEKRLRQQQAEKDSQIKSII GRLMLVEEELRRDHPAMAEP LPEPKKRLLDAQERQLPPLG PTNPRVTLAPPWNGLAPPAP PPPPRLQITENGEFRNTADH |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1244-1343 of human SynGAP (Q96PV0). |
| Post Translational Modifications | Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity. |
| Function | Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits. |
| Protein Name | Ras/Rap Gtpase-Activating Protein SyngapNeuronal RasgapSynaptic Ras Gtpase-Activating Protein 1Synaptic Ras-Gap 1 |
| Database Links | Reactome: R-HSA-5658442 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Ras/Rap Gtpase-Activating Protein Syngap antibodyAnti-Neuronal Rasgap antibodyAnti-Synaptic Ras Gtpase-Activating Protein 1 antibodyAnti-Synaptic Ras-Gap 1 antibodyAnti-SYNGAP1 antibodyAnti-KIAA1938 antibody |
Information sourced from Uniprot.org
