| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SYCP1 (100-400) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SYCP1 |
| Gene ID: |
6847 |
| Uniprot ID: |
SYCP1_HUMAN |
| Immunogen Region: |
100-400 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human SYCP1 (NP_003167.2). |
| Immunogen Sequence: |
EGLSRVYSKLYKEAEKIKKW KVSTEAELRQKESKLQENRK IIEAQRKAIQELQFGNEKVS LKLEEGIQENKDLIKENNAT RHLCNLLKETCARSAEKTKK YEYEREETRQVYMDLNNNIE KMITAFEELRVQAENSRLEM HFKLKEDYEKIQHLEQEYKK EINDKEKQVSLLLIQITEKE NKMKDLTFLLEESRDKVNQL EEKTKLQSENLKQSIEKQHH LTKELEDIKVSLQRSVSTQ |
| Tissue Specificity | Testis. |
| Function | Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. |
| Protein Name | Synaptonemal Complex Protein 1Scp-1Cancer/Testis Antigen 8Ct8 |
| Database Links | Reactome: R-HSA-1221632 |
| Cellular Localisation | NucleusChromosomeCentromereIn Tripartite Segments Of Synaptonemal ComplexesBetween Lateral Elements In The NucleusIts N-Terminus Is Found Towards The Center Of The Synaptonemal Complex While The C-Terminus Extends Well Into The Lateral Domain Of The Synaptonemal ComplexOnly Rarely Detected At Centromeres During Leptotene And ZygoteneDetected At Centromeres During Mid-DiploteneWhen It Is No Longer Present Along Chromosome ArmsNo Longer Detected At Centromeres At Later Stages Of Meiosis |
| Alternative Antibody Names | Anti-Synaptonemal Complex Protein 1 antibodyAnti-Scp-1 antibodyAnti-Cancer/Testis Antigen 8 antibodyAnti-Ct8 antibodyAnti-SYCP1 antibodyAnti-SCP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
