| Host: | Rabbit |
| Applications: | WB/ELISA/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-ATP-dependent RNA helicase SUPV3L1, mitochondrial (443-493 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-P 1:50-300 ELISA 2000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SUPV3L1 |
| Gene ID: | 6832 |
| Uniprot ID: | SUV3_HUMAN |
| Immunogen Region: | 443-493 aa |
| Specificity: | This antibody detects endogenous levels of SUV3 at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human SUV3 at the amino acid range 443-493 |
| Function | Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria.regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. |
| Protein Name | Atp-Dependent Rna Helicase Supv3l1 - Mitochondrial Suppressor Of Var1 3-Like Protein 1 Suv3-Like Protein 1 |
| Database Links | Reactome: R-HSA-9836573 |
| Cellular Localisation | Nucleus Mitochondrion Matrix Mitochondrion Nucleoid |
| Alternative Antibody Names | Anti-Atp-Dependent Rna Helicase Supv3l1 - Mitochondrial antibody Anti-Suppressor Of Var1 3-Like Protein 1 antibody Anti-Suv3-Like Protein 1 antibody Anti-SUPV3L1 antibody Anti-SUV3 antibody |
Information sourced from Uniprot.org
