| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SUN1 |
| Gene ID: |
23353 |
| Uniprot ID: |
SUN1_HUMAN |
| Immunogen Region: |
1-220 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human SUN1 (O94901). |
| Immunogen Sequence: |
MDFSRLHMYSPPQCVPENTG YTYALSSSYSSDALDFETEH KLDPVFDSPRMSRRSLRLAT TACTLGDGEAVGADSGTSSA VSLKNRAARTTKQRRSTNKS AFSINHVSRQVTSSGVSHGG TVSLQDAVTRRPPVLDESWI REQTTVDHFWGLDDDGDLKG GNKAAIQGNGDVGAAAATAH NGFSCSNCSMLSERKDVLTA HPAAPGPVSRVYSRDRNQKC |
| Post Translational Modifications | The disulfide bond with KASH domain-containing nesprins is required for stability of the respective LINC complexes under tensile forces. |
| Function | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). Required for efficient localization of SYNE4 in the nuclear envelope. May be involved in nuclear remodeling during sperm head formation in spermatogenesis. May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links. |
| Protein Name | Sun Domain-Containing Protein 1Protein Unc-84 Homolog ASad1/Unc-84 Protein-Like 1 |
| Database Links | Reactome: R-HSA-1221632 |
| Cellular Localisation | Nucleus Inner MembraneSingle-Pass Type Ii Membrane ProteinAt Oocyte Mi Stage Localized Around The SpindleAt Mii Stage Localized To The Spindle Poles |
| Alternative Antibody Names | Anti-Sun Domain-Containing Protein 1 antibodyAnti-Protein Unc-84 Homolog A antibodyAnti-Sad1/Unc-84 Protein-Like 1 antibodyAnti-SUN1 antibodyAnti-KIAA0810 antibodyAnti-UNC84A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
