Anti-STAM antibody (STJ13100333)

SKU:
STJ13100333-500

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Host: NZ White Rabbit
Applications: IHC/WB
Reactivity: Human/Rat/Mouse/Marmoset
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Nz White Rabbit polyclonal antibody anti-STAM 1, 2 is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Shipped as lyophilised. Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.
Purification: Ammonium sulphate precipitation
Dilution Range: A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: STAM
Gene ID: 8027
Uniprot ID: STAM1_HUMAN
Specificity: Specific for STAM1 & 2.
Immunogen: A synthetic peptide from human STAM 1, 2 (STAM-1, STAM-2) conjugated to blue carrier protein was used as the antigen. The peptide is homologous in many species including rat, mouse, zebra fish and xenopus.
Post Translational Modifications Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB. Ubiquitinated by ITCH.
Function Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. (Microbial infection) Plays an important role in Dengue virus entry.
Protein Name Signal Transducing Adapter Molecule 1
Stam-1
Database Links Reactome: R-HSA-182971
Reactome: R-HSA-5689901
Reactome: R-HSA-6807004
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Reactome: R-HSA-8875360
Reactome: R-HSA-9013420
Reactome: R-HSA-917729
Cellular Localisation Cytoplasm
Early Endosome Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Alternative Antibody Names Anti-Signal Transducing Adapter Molecule 1 antibody
Anti-Stam-1 antibody
Anti-STAM antibody
Anti-STAM1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance