| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ST8SIA2 |
| Gene ID: |
8128 |
| Uniprot ID: |
SIA8B_HUMAN |
| Immunogen Region: |
24-160 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 24-160 of human ST8SIA2 (NP_006002.1). |
| Immunogen Sequence: |
DISEIEEEIGNSGGRGTIRS AVNSLHSKSNRAEVVINGSS SPAVVDRSNESIKHNIQPAS SKWRHNQTLSLRIRKQILKF LDAEKDISVLKGTLKPGDII HYIFDRDSTMNVSQNLYELL PRTSPLKNKHFGTCAIV |
| Tissue Specificity | Highly expressed in fetal brain, kidney and heart and to a much lesser extent in adult heart and thymus. |
| Post Translational Modifications | Autopolysialylated. Autopolysialylation is not a prerequisite for the polysialylation acitity, but enhances the polysialylation acitity. |
| Function | Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan acceptor through alpha-2,8-linkages (Probable). Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides (alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid), including NCAM1, NCAM1 N-glycans, FETUB N-glycans, and to a lesser extent sialylparagloboside (SPG) and AHSG, which does not require the initial addition of an alpha 2,8-sialic acid (Probable). However, does not exhibit sialic acid-polymerase activity. Catalyzes polysialic acid synthesis in the hippocampal on NCAM1 and supports neurite outgrowth. ST8SIA2-mediated polysialylation influences on oligodendrocyte differentiation and may promote the integrity of myelin and axons. |
| Protein Name | Alpha-2 -8-Sialyltransferase 8bSialyltransferase 8bSiat8-BSialyltransferase St8sia IiSt8siaiiSialyltransferase XStx |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-419037Reactome: R-HSA-975577 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinSecretedCell MembraneAlso Trafficks To The Cell Surface |
| Alternative Antibody Names | Anti-Alpha-2 -8-Sialyltransferase 8b antibodyAnti-Sialyltransferase 8b antibodyAnti-Siat8-B antibodyAnti-Sialyltransferase St8sia Ii antibodyAnti-St8siaii antibodyAnti-Sialyltransferase X antibodyAnti-Stx antibodyAnti-ST8SIA2 antibodyAnti-SIAT8B antibodyAnti-STX antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
