| Tissue Specificity | Highly expressed in fetal brain, kidney and heart and to a much lesser extent in adult heart and thymus. |
| Post Translational Modifications | Autopolysialylated. Autopolysialylation is not a prerequisite for the polysialylation acitity, but enhances the polysialylation acitity. |
| Function | Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan acceptor through alpha-2,8-linkages (Probable). Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides (alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid), including NCAM1, NCAM1 N-glycans, FETUB N-glycans, and to a lesser extent sialylparagloboside (SPG) and AHSG, which does not require the initial addition of an alpha 2,8-sialic acid (Probable). However, does not exhibit sialic acid-polymerase activity. Catalyzes polysialic acid synthesis in the hippocampal on NCAM1 and supports neurite outgrowth. ST8SIA2-mediated polysialylation influences on oligodendrocyte differentiation and may promote the integrity of myelin and axons. |
| Protein Name | Alpha-2 -8-Sialyltransferase 8bSialyltransferase 8bSiat8-BSialyltransferase St8sia IiSt8siaiiSialyltransferase XStx |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-419037Reactome: R-HSA-975577 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinSecretedCell MembraneAlso Trafficks To The Cell Surface |
| Alternative Antibody Names | Anti-Alpha-2 -8-Sialyltransferase 8b antibodyAnti-Sialyltransferase 8b antibodyAnti-Siat8-B antibodyAnti-Sialyltransferase St8sia Ii antibodyAnti-St8siaii antibodyAnti-Sialyltransferase X antibodyAnti-Stx antibodyAnti-ST8SIA2 antibodyAnti-SIAT8B antibodyAnti-STX antibody |
Information sourced from Uniprot.org
