• Western blot analysis of lysates from Mouse liver, using ST3GAL4 Rabbit polyclonal antibody (STJ116702) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Anti-ST3GAL4 antibody (125-329) (STJ116702)

SKU:
STJ116702

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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ST3GAL4 (125-329) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ST3GAL4
Gene ID: 6484
Uniprot ID: SIA4C_HUMAN
Immunogen Region: 125-329
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 125-329 of human ST3GAL4 (NP_006269.1).
Immunogen Sequence: LRNSSLGDAINKYDVVIRLN NAPVAGYEGDVGSKTTMRLF YPESAHFDPKVENNPDTLLV LVAFKAMDFHWIETILSDKK RVRKGFWKQPPLIWDVNPKQ IRILNPFFMEIAADKLLSLP MQQPRKIKQKPTTGLLAITL ALHLCDLVHIAGFGYPDAYN KKQTIHYYEQITLKSMAGSG HNVSQEALAIKRMLEMGAIK NLTSF
Tissue Specificity Highly expressed in adult placenta, heart and kidney.
Post Translational Modifications The soluble form derives from the membrane form by proteolytic processing.
Function A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid.Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage. Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets. Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation. Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2. In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively. Metabolizes brain c-series ganglioside GT1c forming GQ1c. Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin.
Protein Name Cmp-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2 -3-Sialyltransferase 4
Alpha 2 -3-St 4
Beta-Galactoside Alpha-2 -3-Sialyltransferase 4
Alpha 2 -3-Sialyltransferase Iv
Gal-Nac6s
Gal-Beta-1 -3-Galnac-Alpha-2 -3-Sialyltransferase
Gal-Beta-1 -4-Glcnac-Alpha-2 -3-Sialyltransferase
N-Acetyllactosaminide Alpha-2 -3-Sialyltransferase
Sat-3
St-4
St3gal Iv
St3galiv
St3gala.2
Stz
Sialyltransferase 4c
Siat4-C
Database Links Reactome: R-HSA-1912420
Reactome: R-HSA-2022854
Reactome: R-HSA-4085001
Reactome: R-HSA-9037629
Reactome: R-HSA-9683673
Reactome: R-HSA-9694548
Reactome: R-HSA-9694719
Reactome: R-HSA-975577
Reactome: R-HSA-977068
Cellular Localisation Golgi Apparatus
Golgi Stack Membrane
Single-Pass Type Ii Membrane Protein
Secreted
Membrane-Bound Form In Trans Cisternae Of Golgi
Secreted Into The Body Fluid
Alternative Antibody Names Anti-Cmp-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2 -3-Sialyltransferase 4 antibody
Anti-Alpha 2 -3-St 4 antibody
Anti-Beta-Galactoside Alpha-2 -3-Sialyltransferase 4 antibody
Anti-Alpha 2 -3-Sialyltransferase Iv antibody
Anti-Gal-Nac6s antibody
Anti-Gal-Beta-1 -3-Galnac-Alpha-2 -3-Sialyltransferase antibody
Anti-Gal-Beta-1 -4-Glcnac-Alpha-2 -3-Sialyltransferase antibody
Anti-N-Acetyllactosaminide Alpha-2 -3-Sialyltransferase antibody
Anti-Sat-3 antibody
Anti-St-4 antibody
Anti-St3gal Iv antibody
Anti-St3galiv antibody
Anti-St3gala.2 antibody
Anti-Stz antibody
Anti-Sialyltransferase 4c antibody
Anti-Siat4-C antibody
Anti-ST3GAL4 antibody
Anti-CGS23 antibody
Anti-NANTA3 antibody
Anti-SIAT4C antibody
Anti-STZ antibody

Information sourced from Uniprot.org

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