| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ST3GAL4 (125-329) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ST3GAL4 |
| Gene ID: |
6484 |
| Uniprot ID: |
SIA4C_HUMAN |
| Immunogen Region: |
125-329 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 125-329 of human ST3GAL4 (NP_006269.1). |
| Immunogen Sequence: |
LRNSSLGDAINKYDVVIRLN NAPVAGYEGDVGSKTTMRLF YPESAHFDPKVENNPDTLLV LVAFKAMDFHWIETILSDKK RVRKGFWKQPPLIWDVNPKQ IRILNPFFMEIAADKLLSLP MQQPRKIKQKPTTGLLAITL ALHLCDLVHIAGFGYPDAYN KKQTIHYYEQITLKSMAGSG HNVSQEALAIKRMLEMGAIK NLTSF |
| Tissue Specificity | Highly expressed in adult placenta, heart and kidney. |
| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. |
| Function | A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid.Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage. Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets. Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation. Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2. In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively. Metabolizes brain c-series ganglioside GT1c forming GQ1c. Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin. |
| Protein Name | Cmp-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2 -3-Sialyltransferase 4Alpha 2 -3-St 4Beta-Galactoside Alpha-2 -3-Sialyltransferase 4Alpha 2 -3-Sialyltransferase IvGal-Nac6sGal-Beta-1 -3-Galnac-Alpha-2 -3-SialyltransferaseGal-Beta-1 -4-Glcnac-Alpha-2 -3-SialyltransferaseN-Acetyllactosaminide Alpha-2 -3-SialyltransferaseSat-3St-4St3gal IvSt3galivSt3gala.2StzSialyltransferase 4cSiat4-C |
| Database Links | Reactome: R-HSA-1912420Reactome: R-HSA-2022854Reactome: R-HSA-4085001Reactome: R-HSA-9037629Reactome: R-HSA-9683673Reactome: R-HSA-9694548Reactome: R-HSA-9694719Reactome: R-HSA-975577Reactome: R-HSA-977068 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneSingle-Pass Type Ii Membrane ProteinSecretedMembrane-Bound Form In Trans Cisternae Of GolgiSecreted Into The Body Fluid |
| Alternative Antibody Names | Anti-Cmp-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2 -3-Sialyltransferase 4 antibodyAnti-Alpha 2 -3-St 4 antibodyAnti-Beta-Galactoside Alpha-2 -3-Sialyltransferase 4 antibodyAnti-Alpha 2 -3-Sialyltransferase Iv antibodyAnti-Gal-Nac6s antibodyAnti-Gal-Beta-1 -3-Galnac-Alpha-2 -3-Sialyltransferase antibodyAnti-Gal-Beta-1 -4-Glcnac-Alpha-2 -3-Sialyltransferase antibodyAnti-N-Acetyllactosaminide Alpha-2 -3-Sialyltransferase antibodyAnti-Sat-3 antibodyAnti-St-4 antibodyAnti-St3gal Iv antibodyAnti-St3galiv antibodyAnti-St3gala.2 antibodyAnti-Stz antibodyAnti-Sialyltransferase 4c antibodyAnti-Siat4-C antibodyAnti-ST3GAL4 antibodyAnti-CGS23 antibodyAnti-NANTA3 antibodyAnti-SIAT4C antibodyAnti-STZ antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
