| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SRGN (28-158) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SRGN |
| Gene ID: |
5552 |
| Uniprot ID: |
SRGN_HUMAN |
| Immunogen Region: |
28-158 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 28-158 of human SRGN (NP_002718.2). |
| Immunogen Sequence: |
YPTRRARYQWVRCNPDSNSA NCLEEKGPMFELLPGESNKI PRLRTDLFPKTRIQDLNRIF PLSEDYSGSGFGSGSGSGSG SGSGFLTEMEQDYQLVDESD AFHDNLRSLDRNLPSDSQDL GQHGLEEDFML |
| Post Translational Modifications | O-glycosylated.contains chondroitin sulfate and heparan sulfate. |
| Function | Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization. |
| Protein Name | SerglycinHematopoietic Proteoglycan Core ProteinPlatelet Proteoglycan Core ProteinP.pgSecretory Granule Proteoglycan Core Protein |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | Cytoplasmic GranuleCytolytic GranuleSecretedExtracellular SpaceGolgi ApparatusFound In Mast Cell Granules And In Cytoplasmic Granules Of Cytolytic T Lymphocytes From Where It Is Secreted Upon Cell ActivationSecreted Constitutively By Endothelial Cells And MacrophagesLocated To Golgi Apparatus During Neutrophil Differentiation |
| Alternative Antibody Names | Anti-Serglycin antibodyAnti-Hematopoietic Proteoglycan Core Protein antibodyAnti-Platelet Proteoglycan Core Protein antibodyAnti-P.pg antibodyAnti-Secretory Granule Proteoglycan Core Protein antibodyAnti-SRGN antibodyAnti-PRG antibodyAnti-PRG1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
