| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SPRY1 |
| Gene ID: | 10252 |
| Uniprot ID: | SPY1_HUMAN |
| Immunogen Region: | 1-170 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human SPRY1 (NP_005832.1). |
| Immunogen Sequence: | MDPQNQHGSGSSLVVIQQPS LDSRQRLDYEREIQPTAILS LDQIKAIRGSNEYTEGPSVV KRPAPRTAPRQEKHERTHEI IPINVNNNYEHRHTSHLGHA VLPSNARGPILSRSTSTGSA ASSGSNSSASSEQGLLGRSP PTRPVPGHRSERAIRTQPKQ LIVDDLKGSL |
| Function | Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells. |
| Protein Name | Protein Sprouty Homolog 1Spry-1 |
| Database Links | Reactome: R-HSA-182971 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinFound In The Cytoplasm In Unstimulated Cells But Is Translocated To The Membrane Ruffles In Cells Stimulated With Egf (Epidermal Growth Factor) |
| Alternative Antibody Names | Anti-Protein Sprouty Homolog 1 antibodyAnti-Spry-1 antibodyAnti-SPRY1 antibody |
Information sourced from Uniprot.org