| Tissue Specificity | Ubiquitously expressed, with highest levels of expression detected in adipose tissue. |
| Post Translational Modifications | Ubiquitinated.ubiquitination does not require ITCH and WWP1. |
| Function | Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons. Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy. Lipid transfer protein required for lipid droplet degradation, including by lipophagy. Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown. May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis. |
| Protein Name | SpartinSpastic Paraplegia 20 ProteinTrans-Activated By Hepatitis C Virus Core Protein 1 |
| Cellular Localisation | CytoplasmMidbodyLipid DropletTransiently Associated With EndosomesColocalized With Ist1 To The Ends Of Flemming Bodies During Cytokinesis |
| Alternative Antibody Names | Anti-Spartin antibodyAnti-Spastic Paraplegia 20 Protein antibodyAnti-Trans-Activated By Hepatitis C Virus Core Protein 1 antibodyAnti-SPART antibodyAnti-KIAA0610 antibodyAnti-SPG20 antibodyAnti-TAHCCP1 antibody |
Information sourced from Uniprot.org
