| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SOX7 (250-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SOX7 |
| Gene ID: |
83595 |
| Uniprot ID: |
SOX7_HUMAN |
| Immunogen Region: |
250-350 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human SOX7 (NP_113627.1). |
| Immunogen Sequence: |
PLHCSHPLGSLALGQSPGVS MMSPVPGCPPSPAYYSPATY HPLHSNLQAHLGQLSPPPEH PGFDALDQLSQVELLGDMDR NEFDQYLNTPGHPDSATGAM A |
| Tissue Specificity | Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation. |
| Function | Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors. May be required for the survival of both hematopoietic and endothelial precursors during specification. Competes with GATA4 for binding and activation of the FGF3 promoter. Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'. |
| Protein Name | Transcription Factor Sox-7 |
| Database Links | Reactome: R-HSA-3769402 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Transcription Factor Sox-7 antibodyAnti-SOX7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
