| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SOX15 (1-50) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SOX15 |
| Gene ID: |
6665 |
| Uniprot ID: |
SOX15_HUMAN |
| Immunogen Region: |
1-50 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-50 of human SOX15 (NP_008873.1). |
| Immunogen Sequence: |
MALPGSSQDQAWSLEPPAAT AAASSSSGPQEREGAGSPAA PGTLPLEKVK |
| Tissue Specificity | Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis. |
| Function | Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence. Acts as a transcriptional activator and repressor. Binds synergistically with POU5F1 (OCT3/4) to gene promoters. Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation. Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG. Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity. Regulates transcription of HRC via binding to it proximal enhancer region. Involved in skeletal muscle regeneration. Also plays a role in the development of myogenic precursor cells. |
| Protein Name | Protein Sox-15Protein Sox-12Protein Sox-20 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Protein Sox-15 antibodyAnti-Protein Sox-12 antibodyAnti-Protein Sox-20 antibodyAnti-SOX15 antibodyAnti-SOX12 antibodyAnti-SOX20 antibodyAnti-SOX26 antibodyAnti-SOX27 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
