| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SNRPD1 (1-119) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SNRPD1 |
| Gene ID: |
6632 |
| Uniprot ID: |
SMD1_HUMAN |
| Immunogen Region: |
1-119 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-119 of human SNRPD1 (NP_008869.1). |
| Immunogen Sequence: |
MKLVRFLMKLSHETVTIELK NGTQVHGTITGVDVSMNTHL KAVKMTLKNREPVQLETLSI RGNNIRYFILPDSLPLDTLL VDVEPKVKSKKREAVAGRGR GRGRGRGRGRGRGRGGPRR |
| Post Translational Modifications | Methylated on arginine residues by PRMT5 and PRMT7.probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs. |
| Function | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA (Probable). |
| Protein Name | Small Nuclear Ribonucleoprotein Sm D1Sm-D1Sm-D AutoantigenSnrnp Core Protein D1 |
| Database Links | Reactome: R-HSA-191859Reactome: R-HSA-72163Reactome: R-HSA-72165Reactome: R-HSA-9754678 |
| Cellular Localisation | CytoplasmCytosolNucleusSmn-Mediated Assembly Into Core Snrnps Occurs In The Cytosol Before Smn-Mediated Transport To The Nucleus To Be Included In Spliceosomes |
| Alternative Antibody Names | Anti-Small Nuclear Ribonucleoprotein Sm D1 antibodyAnti-Sm-D1 antibodyAnti-Sm-D Autoantigen antibodyAnti-Snrnp Core Protein D1 antibodyAnti-SNRPD1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
