| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SNF8 (1-258) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SNF8 |
| Gene ID: |
11267 |
| Uniprot ID: |
SNF8_HUMAN |
| Immunogen Region: |
1-258 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-258 of human SNF8 (NP_009172.2). |
| Immunogen Sequence: |
MHRRGVGAGAIAKKKLAEAK YKERGTVLAEDQLAQMSKQL DMFKTNLEEFASKHKQEIRK NPEFRVQFQDMCATIGVDPL ASGKGFWSEMLGVGDFYYEL GVQIIEVCLALKHRNGGLIT LEELHQQVLKGRGKFAQDVS QDDLIRAIKKLKALGTGFGI IPVGGTYLIQSVPAELNMDH TVVLQLAEKNGYVTVSEIKA SLKWETERARQVLEHLLKEG LAWLDLQAPGEAHYWLPAL |
| Function | Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan. |
| Protein Name | Vacuolar-Sorting Protein Snf8Ell-Associated Protein Of 30 KdaEscrt-Ii Complex Subunit Vps22Hvps22 |
| Database Links | Reactome: R-HSA-917729Reactome: R-HSA-9610379 |
| Cellular Localisation | CytoplasmEndosome MembraneNucleusLate Endosome MembraneRecruited To The Endosome Membrane To Participate In Vesicle Formation |
| Alternative Antibody Names | Anti-Vacuolar-Sorting Protein Snf8 antibodyAnti-Ell-Associated Protein Of 30 Kda antibodyAnti-Escrt-Ii Complex Subunit Vps22 antibodyAnti-Hvps22 antibodyAnti-SNF8 antibodyAnti-EAP30 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
