| Function | Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. |
| Protein Name | Structural Maintenance Of Chromosomes Protein 1bSmc Protein 1bSmc-1-BetaSmc-1b |
| Database Links | Reactome: R-HSA-1221632 |
| Cellular Localisation | NucleusChromosomeCentromereAssociates With ChromatinIn Prophase I Stage Of MeiosisLocalizes Along The Ae Of Synaptonemal ComplexesIn Late-Pachytene-DiploteneThe Bulk Of Protein Dissociates From The Chromosome Arms Probably Because Of Phosphorylation By PlkExcept At CentromeresWhere Cohesin Complexes RemainRemains Chromatin Associated At The Centromeres Up To Metaphase IiAt Anaphase IiDissociates From CentromeresAllowing Chromosomes Segregation |
| Alternative Antibody Names | Anti-Structural Maintenance Of Chromosomes Protein 1b antibodyAnti-Smc Protein 1b antibodyAnti-Smc-1-Beta antibodyAnti-Smc-1b antibodyAnti-SMC1B antibodyAnti-SMC1L2 antibody |
Information sourced from Uniprot.org
