| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC9A9 (1-130) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC9A9 |
| Gene ID: |
285195 |
| Uniprot ID: |
SL9A9_HUMAN |
| Immunogen Region: |
1-130 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human SLC9A9 (NP_775924.1). |
| Immunogen Sequence: |
MERQSRVMSEKDEYQFQHQG AVELLVFNFLLILTILTIWL FKNHRFRFLHETGGAMVYGL IMGLILRYATAPTDIESGTV YDCVKLTFSPSTLLVNITDQ VYEYKYKREISQHNINPHQG NAILEKMTFD |
| Tissue Specificity | Ubiquitously expressed in all tissues tested. Expressed at highest levels in heart and skeletal muscle, followed by placenta, kidney, and liver. Expressed in the brain, in the medulla and spinal cord. |
| Function | Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (Probable). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, e.g., endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters. Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain. Regulates synaptic transmission by regulating the luminal pH of axonal endosomes. Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages. Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH. |
| Protein Name | Sodium/Hydrogen Exchanger 9Na(+/H(+ Exchanger 9Nhe-9Solute Carrier Family 9 Member 9 |
| Database Links | Reactome: R-HSA-425986Reactome: R-HSA-5619052 |
| Cellular Localisation | Late Endosome MembraneMulti-Pass Membrane ProteinEarly Endosome MembraneRecycling Endosome MembraneCell MembraneCytoplasmic VesiclePhagosome MembraneLocalized To The Plasma Membrane In Inner Ear Hair Cell Bundle |
| Alternative Antibody Names | Anti-Sodium/Hydrogen Exchanger 9 antibodyAnti-Na(+/H(+ Exchanger 9 antibodyAnti-Nhe-9 antibodyAnti-Solute Carrier Family 9 Member 9 antibodyAnti-SLC9A9 antibodyAnti-NHE9 antibodyAnti-Nbla00118 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
