| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC8A3 |
| Gene ID: | 6547 |
| Uniprot ID: | NAC3_HUMAN |
| Immunogen Region: | 550-650 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 550-650 of human SLC8A3 (NP_489479.1). |
| Immunogen Sequence: | VKVLRTSGARGTVIVPFRTV EGTAKGGGEDFEDTYGELEF KNDETVKTIRVKIVDEEEYE RQENFFIALGEPKWMERGIS ALLLSPDRKLTMEEEEAKRI A |
| Tissue Specificity | Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle. |
| Function | Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Required for normal oligodendrocyte differentiation and for normal myelination. Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis. |
| Protein Name | Sodium/Calcium Exchanger 3 Na(+/Ca(2+-Exchange Protein 3 Solute Carrier Family 8 Member 3 |
| Database Links | Reactome: R-HSA-418359 Reactome: R-HSA-425561 Reactome: R-HSA-5578775 Reactome: R-HSA-8949215 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Perikaryon Cell Projection Dendrite Dendritic Spine Sarcolemma Cytoplasm Sarcoplasm Cell Junction Mitochondrion Outer Membrane Perinuclear Region Endoplasmic Reticulum Membrane Detected At Neuromuscular Junctions |
| Alternative Antibody Names | Anti-Sodium/Calcium Exchanger 3 antibody Anti-Na(+/Ca(2+-Exchange Protein 3 antibody Anti-Solute Carrier Family 8 Member 3 antibody Anti-SLC8A3 antibody Anti-NCX3 antibody |
Information sourced from Uniprot.org