| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC6A12 (515-614) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC6A12 |
| Gene ID: |
6539 |
| Uniprot ID: |
S6A12_HUMAN |
| Immunogen Region: |
515-614 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 515-614 of human SLC6A12 (NP_003035.3). |
| Immunogen Sequence: |
FSLSKYTPLKYNNVYVYPPW GYSIGWFLALSSMVCVPLFV VITLLKTRGPFRKRLRQLIT PDSSLPQPKQHPCLDGSAGR NFGPSPTREGLIAGEKETHL |
| Tissue Specificity | Expressed in kidney, liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain. |
| Function | Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Probably also involved in renal and hepatic osmotic regulation. |
| Protein Name | Sodium- And Chloride-Dependent Betaine TransporterBgt-1Na(+/Cl(- Betaine/Gaba TransporterSolute Carrier Family 6 Member 12 |
| Database Links | Reactome: R-HSA-352230Reactome: R-HSA-442660Reactome: R-HSA-71288Reactome: R-HSA-888593 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinCell MembraneIn KidneyLocates In Basolateral Membranes Of Renal MedullaIn LiverLocates In Hepatocytes Cell Membrane |
| Alternative Antibody Names | Anti-Sodium- And Chloride-Dependent Betaine Transporter antibodyAnti-Bgt-1 antibodyAnti-Na(+/Cl(- Betaine/Gaba Transporter antibodyAnti-Solute Carrier Family 6 Member 12 antibodyAnti-SLC6A12 antibodyAnti-BGT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
