| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC6A12 |
| Gene ID: | 6539 |
| Uniprot ID: | S6A12_HUMAN |
| Immunogen Region: | 515-614 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 515-614 of human SLC6A12 (NP_003035.3). |
| Immunogen Sequence: | FSLSKYTPLKYNNVYVYPPW GYSIGWFLALSSMVCVPLFV VITLLKTRGPFRKRLRQLIT PDSSLPQPKQHPCLDGSAGR NFGPSPTREGLIAGEKETHL |
| Tissue Specificity | Expressed in kidney, liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain. |
| Function | Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Probably also involved in renal and hepatic osmotic regulation. |
| Protein Name | Sodium- And Chloride-Dependent Betaine Transporter Bgt-1 Na(+/Cl(- Betaine/Gaba Transporter Solute Carrier Family 6 Member 12 |
| Database Links | Reactome: R-HSA-352230 Reactome: R-HSA-442660 Reactome: R-HSA-71288 Reactome: R-HSA-888593 |
| Cellular Localisation | Basolateral Cell Membrane Multi-Pass Membrane Protein Cell Membrane In Kidney Locates In Basolateral Membranes Of Renal Medulla In Liver Locates In Hepatocytes Cell Membrane |
| Alternative Antibody Names | Anti-Sodium- And Chloride-Dependent Betaine Transporter antibody Anti-Bgt-1 antibody Anti-Na(+/Cl(- Betaine/Gaba Transporter antibody Anti-Solute Carrier Family 6 Member 12 antibody Anti-SLC6A12 antibody Anti-BGT1 antibody |
Information sourced from Uniprot.org