Host: | Rabbit |
Applications: | WB/IHC |
Reactivity: | Human/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-SLC30A1 (251-350) is suitable for use in Western Blot and Immunohistochemistry research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 IHC-P 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | SLC30A1 |
Gene ID: | 7779 |
Uniprot ID: | ZNT1_HUMAN |
Immunogen Region: | 251-350 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 251-350 of human SLC30A1 (NP_067017.2). |
Immunogen Sequence: | HVLGDALGSVIVVVNALVFY FSWKGCSEGDFCVNPCFPDP CKAFVEIINSTHASVYEAGP CWVLYLDPTLCVVMVCILLY TTYPLLKESALILLQTVPKQ |
Post Translational Modifications | N-glycosylated at Asn-299. N-glycosylation promotes endocytosis and degradation through the proteasomal or lysosomal pathways. |
Function | Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity. Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells. In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them. |
Protein Name | Proton-Coupled Zinc Antiporter Slc30a1 Solute Carrier Family 30 Member 1 Zinc Transporter 1 |
Database Links | Reactome: R-HSA-435368 |
Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Basolateral Cell Membrane Cytoplasmic Vesicle Membrane Localization To The Plasma Membrane Is Regulated By Cellular Zinc Status Recruitment To The Plasma Membrane From An Internal Pool Is Stimulated By Zinc While In Absence Of Zinc The Plasma Membrane Pool Is Endocytosed And Degraded Localizes To The Basolateral Surface Of Enterocytes Localizes To Zinc-Containing Intracellular Vesicles In Macrophages |
Alternative Antibody Names | Anti-Proton-Coupled Zinc Antiporter Slc30a1 antibody Anti-Solute Carrier Family 30 Member 1 antibody Anti-Zinc Transporter 1 antibody Anti-SLC30A1 antibody Anti-ZNT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance