| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC29A1 |
| Gene ID: | 2030 |
| Uniprot ID: | S29A1_HUMAN |
| Immunogen Region: | 200-300 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human SLC29A1 (NP_001071645.1). |
| Immunogen Sequence: | ELSESAFGYFITACAVIILT IICYLGLPRLEFYRYYQQLK LEGPGEQETKLDLISKGEEP RAGKEESGVSVSNSQPTNES HSIKAILKNISVLAFSVCFI F |
| Tissue Specificity | Expressed in testis at the blood-testis barrier (at protein level). Detected in erythrocytes (at protein level). Expressed at relatively high levels in cerebral cortex, particularly the frontal and parietal lobes, and the thalamus and basal ganglia (at protein level). In the midbrain expressed at moderate levels, whereas in the other areas of the brainstem, namely medulla and pons, cerebellum and the hippocampus expressed at lower amounts when compared to the other brain regions (at protein level). Expressed in Langerhans cells and lymphocytes in the pancreas (at protein level). Expressed in kidney, in polarized renal epithelial cells. Expressed in adipose tissues. Expressed in placenta. Expressed in small intestine. |
| Post Translational Modifications | Glycosylated. |
| Function | Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis. Functions as a Na(+)-independent transporter. Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine. Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier. Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure. |
| Protein Name | Equilibrative Nucleoside Transporter 1 Hent1 Equilibrative Nitrobenzylmercaptopurine Riboside-Sensitive Nucleoside Transporter Equilibrative Nbmpr-Sensitive Nucleoside Transporter Es Nucleoside Transporter Nucleoside Transporter - Es-Type Solute Carrier Family 29 Member 1 |
| Database Links | Reactome: R-HSA-83936 Reactome: R-HSA-9748787 Reactome: R-HSA-9755088 |
| Cellular Localisation | Basolateral Cell Membrane Multi-Pass Membrane Protein Apical Cell Membrane Cell Membrane Localized To The Basolateral Membrane Of Sertoli Cells Localized To The Cell Membrane Of Erythrocytes |
| Alternative Antibody Names | Anti-Equilibrative Nucleoside Transporter 1 antibody Anti-Hent1 antibody Anti-Equilibrative Nitrobenzylmercaptopurine Riboside-Sensitive Nucleoside Transporter antibody Anti-Equilibrative Nbmpr-Sensitive Nucleoside Transporter antibody Anti-Es Nucleoside Transporter antibody Anti-Nucleoside Transporter - Es-Type antibody Anti-Solute Carrier Family 29 Member 1 antibody Anti-SLC29A1 antibody Anti-ENT1 antibody |
Information sourced from Uniprot.org