| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC22A6 (31-135) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC22A6 |
| Gene ID: |
9356 |
| Uniprot ID: |
S22A6_HUMAN |
| Immunogen Region: |
31-135 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 31-135 of human SLC22A6 (NP_004781.2). |
| Immunogen Sequence: |
MASHNTLQNFTAAIPTHHCR PPADANLSKNGGLEVWLPRD RQGQPESCLRFTSPQWGLPF LNGTEANGTGATEPCTDGWI YDNSTFPSTIVTEWDLVCSH RALRQ |
| Tissue Specificity | Strongly expressed in kidney. Expressed at lower level in liver, skeletal muscle, brain and placenta. In kidney, found at the basolateral membrane of the proximal tubule. In testis, primarily localized to the basal membrane of Sertoli cells and weakly expressed in Leydig cells and vascular endothelial cells. |
| Post Translational Modifications | Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane. |
| Function | Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate. Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion. Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP. Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain. May transport glutamate. Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body. Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate (CMPF) and urate. Xenobiotics include the mycotoxin ochratoxin (OTA). May also contribute to the transport of organic compounds in testes across the blood-testis-barrier. |
| Protein Name | Solute Carrier Family 22 Member 6Organic Anion Transporter 1Hoat1Pah TransporterHpahtRenal Organic Anion Transporter 1Hroat1 |
| Database Links | Reactome: R-HSA-561048 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinBasal Cell MembraneLocalized To The Basolateral Membrane Of Renal Proximal Tubular CellsLocalized To The Basal Membrane Of Sertoli Cells |
| Alternative Antibody Names | Anti-Solute Carrier Family 22 Member 6 antibodyAnti-Organic Anion Transporter 1 antibodyAnti-Hoat1 antibodyAnti-Pah Transporter antibodyAnti-Hpaht antibodyAnti-Renal Organic Anion Transporter 1 antibodyAnti-Hroat1 antibodyAnti-SLC22A6 antibodyAnti-OAT1 antibodyAnti-PAHT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
